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deskgameA Week 13 showdown with the Lions, however, could impact the odds more than any other single game going forward. If the Bills can take down Detroit on the road, combined with wins over the Chiefs and 49ers, who will still be held in higher regard, they may actually move into the top spot despite Allen’s crew not reaching the Super Bowl to this point, deskgameNotre Dame quarterback Riley Leonard runs the ball during the second half of an NCAA college football game against Southern California, Saturday, Nov. 30, 2024, in Los Angeles. deskgameAs the NFL Week 11 odds open, sportsbooks view Philadelphia as 3 to 3.5-point favorites, depending on the platform. The over/under for the game is between 49 and 49.5. deskgameWeekly NFL Bet Boosts: bet365 offers daily betting boosts for all its regular season NFL contests.